Starting from the year 2000, he embarked on experimenting with the use of the web in the language of comics through the project inguine.net, which later gave rise to the publication of the magazine inguineMAH!gazine by Coniglio Editore.

His artistic career began with collaboration on the Indymedia portal, focusing on significant political events such as street protests and revolutions that have characterized the global landscape.

[5] Starting in 2014, Costantini has focused his artistic talent on human rights, with a particular emphasis on the conditions of detainees in places such as Bahrain, Saudi Arabia, China, Turkey and Egypt.

In 2022, Gianluca Costantini published a graphic novel written by Laura Cappon, titled "Patrick Zaki, una storia egiziana," released by Feltrinelli Editore.

[11][12][13] Throughout 2019, during the legal proceedings involving Ai Weiwei and Skandinavisk Motor Co. A/S in Copenhagen, Gianluca Costantini assumed the role of a visual documentarian, capturing the events through his drawings.

[14] His involvement was directly solicited by Ai Weiwei, given that the proceedings were conducted behind closed doors, and it was deemed crucial to preserve an accurate visual record of what transpired.

[3] In 2022, Costantini began to document and visually represent the Iranian protests in response to the killing of the twenty-two-year-old Mahsa Amini, an event that shook the international community.

[15] Through his work, Costantini aimed to amplify the voices of Iran women and draw global attention to crucial issues related to freedom and human rights.

[16] His works have been exhibited in many cities worldwide, including Paris,[17] Milan, London, Berlin, Denver, Los Angeles, Vancouver, Fribourg, Tallinn, and Ottawa, reaching a broad international audience.

[18][19] Costantini's solo exhibition, titled "La strage dei fiori" (The Massacre of Flowers), garnered significant interest and provided the audience with an opportunity to reflect on the complex and often dramatic realities characterizing the situation in Iran.

This biography, crafted through the amalgamation of visual storytelling and written text, represents a detailed homage to this prominent figure in the Ottoman cultural landscape.

This illustrated biography provides an opportunity for the reader to explore the historical and cultural context in which Osman Hamdi Bey operated, emphasizing his diverse activities and his impact on Turkey's artistic and museal heritage.

The narrative offers a detailed perspective on Assange's figure, exploring the key role he played in the creation and evolution of WikiLeaks, as well as the historical context of the group's activities.

The graphic novel trilogy is characterized by a unique fusion of visual storytelling and written text, providing an in-depth exploration into the lives of significant historical figures in Italian history.

Created in 2014 by Gianluca Costantini and Elettra Stamboulis for the Italian publishing house Eris Edizioni, this work provides a deep and poignant insight into the reality of war and the challenges faced by soldiers.

In 2019, he released the graphic novel "Libia," a collaborative work between the renowned artist Gianluca Costantini and the acclaimed journalist Francesca Mannocchi.

This work, through the powerful combination of visual art and narrative journalism, aims to explore the complex dynamics and challenges faced by Libya, a country rich in history and conflicts.

This graphic memoir deeply explores the connection between artistic expression and intellectual freedom, providing a unique perspective through the lens of the Chinese zodiac.

This compelling piece of visual storytelling delves into historical narratives, and its critical text by Sabina Ghinassi adds depth to the exploration of the Gothic Line.

The critical text by Tahar Lamri accompanies the catalog, offering a thoughtful analysis of Costantini's visual exploration of themes related to Algeria.

Within the pages of this magazine, significant contributions were made by prominent international authors, including Joe Sacco, Julie Doucet, Blu, Miguel Brieva, Max Andersson, James Kochalka, Eric Drooker, Aleksandar Zograf, and many others...[15] From 2009 to 2015, Gianluca Costantini served as the artistic director and editor-in-chief of the G.I.U.D.A.