[8] He spent the entire 2016 season playing with Columbus and in the offseason he played winter baseball in the Venezuelan Professional Baseball League for Águilas del Zulia alongside future Yankees teammate Mike Tauchman.

[13] On May 9, 2018, Cleveland traded Urshela to the Toronto Blue Jays for cash considerations or a player to be named later.

[13] On August 4, 2018, the Blue Jays traded Urshela to the New York Yankees in exchange for cash considerations.

He worked with Phil Plantier, the RailRiders' hitting coach, to make changes to his batting stance.

He played in 43 of the team's 60 games, missing time with a groin injury in late August.

[21] He batted .298/.368/.490 with 6 home runs and 30 RBIs, and led all qualifying third basemen with a .992 fielding percentage.

On September 30, in Game 2 of the AL Wild Card Series, Urshela became the first Yankees third baseman to hit a postseason grand slam doing so against his former team, the Cleveland Indians.

On March 13, 2022, the Yankees traded Urshela and Gary Sánchez to the Minnesota Twins in exchange for Josh Donaldson, Isiah Kiner-Falefa and Ben Rortvedt.

[25] In October 2022, it was announced that Urshela would spend the 2022 offseason playing with his hometown Tigres de Cartagena of the Colombian Professional Baseball League.

[33] On August 20, 2024, Urshela signed a one-year, major league contract with the Atlanta Braves.

[39] Urshela was named to the Colombian roster for the 2026 World Baseball Classic qualifiers, held in March 2025 in Tucson, Arizona.