Santiago Jesus Florez (born May 9, 2000) is a Colombian professional baseball pitcher who is a free agent.

[1] He made his professional debut for the Dominican Summer League Pirates, starting 14 contests and posting a 4.56 ERA with 30 strikeouts.

[3] In 2019, he pitched for the rookie–level Bristol Pirates, making 10 starts and registering a 2–2 record and 3.46 ERA with 36 strikeouts across 41+2⁄3 innings of work.

[9] On January 30, 2024, Florez signed with the Sioux City Explorers of the American Association of Professional Baseball.

[13] Florez was part of the Colombian squad that won the gold medal at the 2023 Pan American Games contested in Santiago, Chile in October 2023.