On May 29, 2012, Solano was called up to the majors by the Nationals after Wilson Ramos tore his ACL and could miss the rest of the 2012 season.

On that same day, Solano got his first major league hit, a double, on his first at bat, against his brother Donovan's team, the Miami Marlins.

About two weeks later, on June 12, he hit the first home run of his major league career against the Toronto Blue Jays[1] On July 19, the Nationals placed Solano on the 15-day disabled list with an oblique injury.

[5] Solano had his contract purchased on April 7, 2018, but was assigned to the disabled list with bone chips in his elbow days later without appearing in a game.

[9] In 2024, it was announced that Solano would manage the Tigres de Cartagena club of the Colombian Professional Baseball League.