Giovanni di Cosimo de' Medici (3 June 1421[1] – 23 September 1463) was an Italian banker and patron of arts.

In 1454 Giovanni was elected Prior of Florence and the following year he was a member of the delegation which received Pope Pius II in the city.

The following year Cosimo made him general director of the Medici bank, but, unsatisfied because of Giovanni's distraction in arts and other activities, assigned to him Francesco Sassetti as tutor.

[3] This marriage recognized the support that Niccolò had provided to Cosimo during his exile in 1433, and bound the families together.

He had the Villa Medici in Fiesole built by Michelozzo Michelozzi (but probably in collaboration with Giovanni's friend, Leon Battista Alberti).