Girlamatic was created as a place where both female artists and readers could feel comfortable and featured a diverse mix of genres.

The editorial role was held by Hernandez from 2003 until 2006, when it was taken over by Arcana Jayne-creator Lisa Jonté, one of the site's original artists.

"[5] Lisa Jonté stated that Girlamatic's inclusion criteria were essentially "whatever appeals to the editor ... we want engaging stories with well-developed characters."

"[2] Girlamatic was the third webcomic subscription service launched and managed by Joey Manley, following the success of Modern Tales and Serializer.net.

[7][8] Girlamatic launched on March 31, 2003 with sixteen artists: Donna Barr, Vera Brosgol, Kris Dresen, Shaenon K. Garrity, Lisa Jonté, Layla Lawlor, Jenn Manley Lee, Dylan Meconis, Andre Richard, Harley Sparx, Spike Trotman, Jason Thompson, Carla Speed McNeil, Rachel Hartman, Jesse Hamm, and Tochi.

During this period, all of Joey Manley's websites merged into comics-oriented social media and publishing platform ComicSpace, which he developed in collaboration with OnlineComics.net creator Josh Robert.

Two new webcomics were added to the Girlamatic roster during its 2009 relaunch: The Continentals by Darryl Hughes and Monique McNaughton, and Godseeker by Lisa Gilbert and Terry Blauer.

He also voiced concern that initiatives like Girlamatic might section off and divide the webcomic community, making it less likely for male readers to come across the works of female webcartoonists.