Soon after, she was invited to the webcomics anthology site Girlamatic and produced her first professional comic, a web serial entitled I Was There & Just Returned.

[5] Afterwards, Larson concentrated on a number of small, hand-made minicomics, combining her interests in comics, screenprinting, and bookmaking.

She contributed to comics anthologies Flight, True Porn 2, and You Ain't No Dancer, while working on a web-serialized graphic novel, Salamander Dream.

[7] In 2012, Larson adapted Madeleine L'Engle's work as A Wrinkle in Time: The Graphic Novel, published by Margaret Ferguson Books (a Farrar Straus Giroux imprint).

[8] In 2016, Larson became the new writer for DC Comics Batgirl,[9] a run that saw the character go on back-packing trip through Asia on a voyage of self-discovery.

[16] Rebecca Kraatz's House of Sugar, Larson's first publishing venture, won the 2007 Doug Wright Award for Best Emerging Talent.