Glade Creek is a major tributary of the New River in Raleigh County, West Virginia.

Glade Creek is formed on Flat Top Mountain just north of the point where Raleigh, Summers and Mercer counties intersect.

Just north of its source near Ghent, it is impounded to form Flat Top Lake.

Much of the lower canyon is traversed by an abandoned railroad bed.

Approximately 5 miles (8.0 km) upstream of its mouth, Glade Creek is crossed by Interstate 64 on the Phil G. McDonald Memorial Bridge, also known as the Glade Creek Bridge.