Glipizide, sold under the brand name Glucotrol among others, is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes.

[1] Common side effects include nausea, diarrhea, low blood sugar, and headache.

[1] In 2022, it was the 42nd most commonly prescribed medication in the United States, with more than 14 million prescriptions.

[2] Glipizide acts by partially blocking potassium channels among beta cells of pancreatic islets of Langerhans.

The resulting calcium influx encourages insulin release from beta cells.