The Globidensini or Globidentatini are a tribe of mosasaurine mosasaurs, a diverse group of Late Cretaceous marine squamates.

[6] Features of the maxilla and digits make the placement of Carinodens and Xenodens in the tribe uncertain; some researchers have suggested that they may be more appropriately placed in the Mosasaurini.

[6] Towards the end of the Cretaceous, a series of adaptations allowed the highly specialized mosasaurs within the Globidensini, characterized by knob-like teeth,[7] to successfully reclaim the niche of the durophagous lifestyle.

Most mosasaur genera have sharp teeth adapted to grab soft and slippery prey like fish and cephalopods.

The ratio between the length of the supratemporal fenestra and the total length of the skull has previously been used as an improvised measurement for mosasaur bite force, and is quite high in these genera (0.27 in Globidens dakotensis and 0.22 in Prognathodon overtoni and P. saturator) compared to other mosasaurs like Mosasaurus hoffmannii (with a ratio of 0.19).