Glottiphyllum fergusoniae is a species of succulent plant, of the family Aizoaceae.

The leaves are decussate (produced in alternate, perpendicular pairs) slender, erect and tapering gradually to a point.

This species occurs in the western part of the Little Karoo, South Africa.

Glottiphyllum depressum, which co-occurs with it in the same areas, is found only on shadier, more sheltered spots, growing in deeper soils.

A third species, Glottiphyllum suave occurs just to the north of its range, also in the western Little Karoo, has a pale waxy covering to its leaves, and favours exposed positions.