Glucocorticoid remediable aldosteronism

Aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex.

Aldosterone synthase normally is not ACTH sensitive, and is only activated by angiotensin II.

[citation needed] The genes encoding aldosterone synthase and 11β-hydroxylase are 95% identical and are close together on chromosome 8.

[citation needed] The product of this hybrid gene is aldosterone synthase that is ACTH-sensitive[2] in the zona fasciculata of the adrenal gland.

[4] Genetic testing is done to ascertain that the individual in question does indeed have the condition[5] In GRA, the hypersecretion of aldosterone and the accompanying hypertension are remedied when ACTH secretion is suppressed by administering glucocorticoids.