Glycine methyl ester hydrochloride is the organic compound with the formula [CH3O2CCH2NH3]Cl.

A white, water-soluble solid, it is the hydrochloride of the methyl ester of the amino acid glycine.

Glycine methyl ester hydrochloride can be prepared by treatment of glycine with 2 equivalents of trimethylsilyl chloride, followed by the addition of methanol.

[2][3] Upon treatment with base, the salt converts to glycine methyl ester.

[4] Glycine methyl ester (and other esters of glycine) are not shelf-stable, tending to polymerize when stored at room temperature[4] or convert to diketopiperazine.