"Go Missin'" contains similar characteristics to "Climax"; it is a quiet storm-style mid-tempo R&B track, and incorporates heavy bass and synthesizers.

[3][4] The song was produced by Diplo, who previously collaborated with Usher on the track "Climax", which was released as the lead single from the latter's seventh studio album, Looking 4 Myself (2012).

[7] Brown described the track as to be "full of roiling snares and boomy bass kicks" while saying that Usher's vocals are "so pristine" that they walk a line between "digital witch-magic and the hair-raising choral work of Ligeti.

"[7] About.com's Mark Edward Nero described the collaboration as "innovative", and thought that the track contained a "cinematic quality with delicate vocals laid over a moody, semi-futuristic electronic beat".

[9] Billboard's David Greenwald compared "Go Missin'" to the work of Canadian singer The Weeknd, while describing Usher's vocals as "seductive".