Mosquito Gulf (Spanish: Golfo de los Mosquitos) is a gulf of the Caribbean Sea on the north coast of Panama, extending from the Valiente Peninsula in Bocas del Toro, past the north coast of Veraguas to the province of Colón, Panama.

[1] It should not be confused with the Mosquito Coast which is further north in Nicaragua and Honduras.

The Isla Escudo de Veraguas is the primary island in the gulf.

The Golfo de los Mosquitos forests are the largest block of lowland forest on the Caribbean slope between Bocas del Toro and the San Blas Islands.

[2] It is threatened by development for cattle and subsistence agriculture, as well as the discovery of a nearby copper deposit.