The hospital is located off of the Mpigi–Kabulasoke–Maddu–Sembabule Road, in the central business district of the town of Gombe, approximately 70 kilometres (43 mi) southwest of Mulago National Referral Hospital.

[1] This is about 81 kilometres (50 mi) northeast of Masaka Regional Referral Hospital.

[2] Gombe Hospital was established in 1969 by the first government of Prime Minister Milton Obote.

[4] In 2013, the hospital's laboratory, underwent renovations under a joint program by PEPFAR and USAID, known as SUSTAIN.

[6] In 2015, the hospital adopted palliative care, as part of its vision and mission.