TriHealth Good Samaritan Hospital is the oldest and largest private teaching and specialty health care facility in Cincinnati, Ohio.

[citation needed] The hospital is member of TriHealth, a joint operating agreement between Catholic Health Initiatives and Bethesda, Inc. Cincinnati to manage Good Samaritan.

[citation needed] Four members of the medical staff of St. John's Hospital, as it had become known, paid the costs of relocating and renovating an old colonial mansion at the corner of Third and Plum Streets to accommodate 70 beds.

[citation needed] A destitute man suffering from typhoid fever passed a long recovery at St. John's and when he recovered, the sisters gave him a job.

[citation needed] A local banker, Joseph C. Butler, had referred the man to the hospital, and when he attempted to pay the man's bills, the sisters dismissed the charges, explaining that their care was “for the love of God.”[citation needed] Impressed, Butler and his friend Louis Worthington purchased a large hospital that was being sold by the U.S. government at the close of the Civil War.

[citation needed] Longtime benefactor Joseph C. Butler Jr. was contacted and again gave generously, providing the sisters with 6 acres (24,000 m2) adjoining the property they had purchased.

[citation needed] One of the hospital's original wings was removed in order to construct the Dixmyth Visitor Garage and Ambulatory Surgery Center in the late 1980s.