The Goodhope River is a stream, 46 miles (74 km) long, on the Seward Peninsula in the U.S. state of Alaska.

[1] It heads about 5.3 miles (8.5 km) west-southwest of Cloud Lake and flows generally northeast to Goodhope Bay on Kotzebue Sound of the Chukchi Sea.

[1] The river mouth is about 27 miles (43 km) west of Cape Deceit and Deering in the Northwest Arctic Borough.

[1] The entire course of the river lies within the Bering Land Bridge National Preserve.

Explorer Otto von Kotzebue assigned the name to the bay, which he visited in 1816, because he had good hope of making important geographic discoveries in the region.