Located in Edmonton's Glenora neighbourhood, since 1964 the restored and repurposed building has been used by the Alberta provincial government for ceremonial events, conferences, and some official meetings of the caucus.

Government House is about a 4-kilometre (2.5 mi) walk from the Alberta Legislature Building, northwest along the banks of the North Saskatchewan River.

Construction on the building, intended from the outset to house the lieutenant governor, began in 1912, and the official opening was held on October 7, 1913.

However, the closure also came soon after Lieutenant Governor John C. Bowen refused to grant royal assent to three controversial bills passed through the Legislative Assembly, and was, along with the removal of his support staff and official car, seen as an act of retaliation by Premier William Aberhart.

The building was used a boarding house for American pilots flying supplies up to the Alaska Highway and then was acquired by the federal government as military hospital during the Second World War.

From 1938 until 2005, Alberta owned and operated an official residence, a separate office, and provided an entertaining venue for the viceroy.