In organic chemistry, the Graham reaction is an oxidation reaction that converts an amidine into a diazirine using a hypohalite reagent.
The halide of the hypohalite oxidant, or another similar anionic additive to the reaction, is retained as a substituent on the diazirine product.
[2][3] Amidine substrates for the reaction can easily be formed from the corresponding nitriles via the Pinner reaction.
The halide substituent in the diazirine product can be displaced by a various nucleophiles.
[4] This organic chemistry article is a stub.