Western North Yorkshire (Settle), northern Staffordshire (Biddulph and Kidsgrove) and northwest of Derbyshire (Buxton, Glossop, New Miils and Chapel-en-le-Frith) get their signals from the Winter Hill TV transmitter that broadcasts Granada Reports rather than the neighbouring regions of ITV News Calendar and ITV News Central.

Within a year, Granada established its first regular bulletin - Northern Newscast - followed by a topical magazine programme, People and Places,[2] noted for featuring some of the earliest television appearances by The Beatles.

Up until 1962, the station was also producing topical output in the Welsh language, primarily for Welsh-speaking viewers in North Wales, including daily news bulletins and a magazine programme, Dewch i Mewn (Do Come In).

[6][7] Following changes to the company's franchise, including a new brief to solely cover the North West, Scene was axed in 1968 and replaced by six self-contained regional programmes, preceded by a short Granada News bulletin.

For much of its run, Granada Tonight placed a greater emphasis on non-news features and entertainment content, with its studio set consisting of sofas and armchairs.

On 27 September 2012, it was announced technical staff had been invited to volunteer for redundancy as part of national job losses affecting ITV News services.