It is based in Luxembourg City, in the south of the country.
The Institute incorporates six subsections, each dedicated to a separate field of academic research: The "Royal Grand Ducal Institute" was created on 24 October 1868 from the merger of three organisations, the Société archéologique, the Société des sciences naturelles and the Société des sciences médicales.
In 1962, a fifth was added, the Section des arts et lettres.
The sixth was added in 1966: the Section des sciences morales et politiques.
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