Grand Ecore is an unincorporated community in Natchitoches Parish, Louisiana, United States.

The US Army Corps of Engineers operates a visitor center at Grand Ecore with panamoramic views from the bluff 80 feet above the Red River.

Over the next 70 years, the French then the Spanish colonial governments issued land grants to Bossier, Grappe, Prudehomme, Brevelle, and Metoyer.

By the turn of the century, Dr. Sibley bought Grand Ecore and 500 acres on the opposing bank of the Red River.

Fort Selden on Bayou Pierre, above Grand Ecore, was established in 1820 by companies of the 7th Infantry from Arkansas.