The Grand Glaize Bridge is the name of two girder bridges that carry U.S. Route 54 over the Grand Glaize Arm of the Lake of the Ozarks in the city of Osage Beach, Missouri.

The bridge crosses Grand Glaize Creek that is a tributary to the Osage River in Camden County, Missouri.

The original two-lane Grand Glaize Bridge was built in 1931 during the construction of Bagnell Dam and the Lake of the Ozarks.

The new parallel girder bridge carrying westbound traffic was completed in 1984.

In 2023, both the eastbound bridge and westbound underwent rehabilitation by placing epoxy-wearing on the surface.