Granny Creek is a stream in Bollinger and Cape Girardeau counties in the U.S. state of Missouri.
The stream headwaters are in Cape Girardeau County about two miles southwest of Gravel Hill on Missouri Route 34 and just east of the county line.
The stream flows south-southwest into Bollinger County and continues to the south roughly parallel to the county line.
The confluence with Hog Creek is about 1.5 mile northwest of Lake Girardeau and the village of Crump.
This article related to a river in Missouri is a stub.