[1] However, as GLILD is often associated with other auto-immune features such as splenomegaly, adenopathy and cytopenias, a definition based on abnormalities on lung imaging (CT scan) together with evidence of granulomatous inflammation elsewhere has also been employed.
Typical features on CT include solid and sub-solid nodules, ground glass change and reticulation.
[citation needed] The commonest abnormality on lung function testing is a decrease in gas transfer.
Exclusion of infection is therefore an important step in management, but confirmation of the diagnosis requires lung biopsy.
[citation needed] There are no current guidelines available on the investigation and management of GLILD and evidence is restricted to retrospective case series.
[9] Immunosuppression has been associated with development of opportunistic infection[2] and other predictable side effects, and the balance of risks and benefits of therapy must be carefully weighed in each case.