Granulomatous prostatitis is an uncommon disease of the prostate, an exocrine gland of the male reproductive system.

[1] It is a form of prostatitis (prostate inflammation), resulting from infection (bacterial, viral, or fungal), BCG vaccine, malacoplakia or systemic granulomatous diseases which involve the prostate.

Prostatic secretions escape into the stroma and elicit an inflammatory response.

[2] Granulomatous prostatitis can be mistaken for prostate cancer, including on rectal examination, MRI, and heightened PSA scores.

[6] One study stated prevalence in 0.44% in routine prostatectomy specimens, 0.29% in needle biopsies, and 0.77% of TURP, simple prostatectomy, and needle biopsy.