Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types.

It is thus not surprising that targeted gene disruption of Grb2 in mice is lethal at an early embryonic stage.

Gads and Grap are expressed specifically in hematopoietic cells and function in the coordination of tyrosine kinase mediated signal transduction.

The SH2 domain of Grb2 binds to phosphorylated tyrosine-containing peptides on receptors or scaffold proteins with a preference for pY-X-N-X, where X is generally a hydrophobic residue such as valine (see [1]).