Greasy Creek is a stream in Madison County in the U.S. state of Missouri.
The stream headwaters arise at 37°28′49″N 90°15′39″W / 37.48028°N 90.26083°W / 37.48028; -90.26083 southwest of Missouri Route A. the stream floes to the southeast parallel to Route A and passes the community of Klendike.
It gradually turns to the east and passes under Route A to its confluence with the Castor River just to the north of Marquand at 37°26′14″N 90°10′35″W / 37.43722°N 90.17639°W / 37.43722; -90.17639.
[2][1] Greasy Creek was named for the greasewood timber near its course, according to local history.
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