The school bears the name of the former Great Crossing School, which opened in 1939 and was in turn named for one of the Georgetown area's first settlements, established at a buffalo crossing of Elkhorn Creek.

It is located about 1 mile (1.6 km) away from Scott County High and also adjacent to Elkhorn Crossing School, previously a detached campus of Scott County High.

Construction was plagued by unusually wet weather, with 247 rain days during the project.

[7] Initially, SCS announced that all rising juniors and seniors for 2019–20 at Scott County High could remain at that school if they wished.

[8] SCS later changed the plan to allow all students who were set to attend high school in the district to choose which school they would attend, and about 55% chose Great Crossing.