[3] Its lower reaches are tidal, with broad mud flats, and drain the eastern coast of the city of Calabar.
[3] Human activity in the Great Kwa basin has traditionally been limited to small scale farming, aquaculture and artisanal fisheries, mainly for shrimp.
[4] However, Calabar is growing, due in part to the Calabar Free Trade Zone, causing growing numbers of houses and factories to be built in the freshwater and mangrove swamps of the Great Kwa.
The university has acquired more land on both banks of the Great Kwa for future development.
[3] A 2008 study of Vibrio bacteria in shellfish in the Great Kwa River estuary showed that the water was constantly faecally polluted, and the shellfish had high levels of infection.