By the mid-19th century it was described as being in an area of "dirty shops and dingy private dwellings...where children never washed" (quote from Pevsner and Cherry, 1991, London 3: North West).
However, in February 1900, F.S.Webster, rector of the All Souls Church, Langham Place described how "the locality east of Great Titchfield Street is rapidly changing.
The garment industry, historically important in the East Marylebone and Soho areas, continues to have a presence in Great Titchfield Street.
The radio & television stations of the Canadian Broadcasting Corporation have their UK Office & Administration headquarters at 43-51 Great Titchfield Street.
Like Charlotte Street, its near neighbour to the east, Great Titchfield Street is also home to a diverse range of specialist restaurants including Scandinavian Kitchen (Norwegian, Swedish and Danish), HT Harris (Italian Delicatessen), Efes (Turkish), Sergios (Italian Cafe), Shikara (North Indian) and the Riding House Fitzrovia.