The Hellenic Olympic Committee sent a total of 103 athletes to the Games in London, 65 men and 38 women, to compete in 19 sports.

Greece failed to win a gold or a silver medal for the first time since 1988 Summer Olympics in Seoul.

Several athletes missed out of the medal standings in the finals, including swimmer Spyridon Gianniotis (fourth in the open water marathon), the Men's coxle four team (finished in the fourth place), Vassiliki Vougiouka (missed out the semi-finals in fencing), sailor Byron Kokkalanis, (sixth in men's windsurfing) and gymnast Vasileios Tsolakidis (sixth in men's parallel bars).

Based on their world rankings as of 16 May 2011 Kalinikos Kreanga and Panagiotis Gionis qualified for the men's event.

[6] Alexandros Nikolaidis had ensured a quota place for Greece in the men's +80 kg by reaching the top 3 of the 2011 WTF World Qualification Tournament.