The building was listed on the National Register of Historic Places on February 28, 1997, as part of the architectural legacy of Proudfoot and Bird in Iowa.

In 1928, the immigrants organized a Greek Orthodox parish named for St. George the Great Martyr, which held services with visiting priests on an irregular basis in rented spaces.

Orthodox icons have been added to the interior over time, but the building retains many artifacts of the original Presbyterian congregation such as the stained glass windows.

On November 4, 1997, the Ecumenical Patriarch of Constantinople, Bartholomew I, visited St. George Parish.

Cultural events and educational programs sponsored by the parish include the Greek School for Children, a youth Sunday School program, active chapters of Greek Orthodox Youth of America (GOYA) and Junior Orthodox Youth (JOY), an adult Greek School, a monthly Adult Synaxis (the parish adult education program), a women's Bible study program, and an annual Greek Food Fair held during the first weekend in June.