The privately owned main building was at Juan Luna St., while Fugoso Annex was located at the corner of Tapuri and Yangco.

The new school was supervised by Fabian Bugayong as second principal, Leonor Zapanta as head teacher and Aurelio Libao as guidance counselor.

There were series of petitions and efforts made during the time of Domingo Quiambao, Miss Ines Villanueva and Bartolome del Valle to house Gregorio Perfecto High School in a new building and location from its previous site at Gagalangin, Tondo.

Construction of the new building for Gregorio Perfecto High School started in April 1964 in Ricafort St., Tondo.

Many resolutions had pushed by the school administration until it materialized in 2014, the time of many news regarding the Big One, expected catastrophic earthquake that might hit the West Valley Fault along Metro Manila and Southern Luzon.

The assistance of De La Salle University under the Partnership for Educational Change forged in 2000 and later the Operation Big Brother (OBB) for selected classes, which spurs the quest for excellence.

Principal Miss Angela Y. Ong and later Mr. Arnulfo H. Empleo lent administrative and managerial know how as the school turned the corner.