Grieco three-component condensation

The Grieco three-component condensation is an organic chemistry reaction that produces nitrogen-containing six-member heterocycles via a multi-component reaction of an aldehyde, a nitrogen component, such as aniline, and an electron-rich alkene.

[1][2] In the original paper the nitrogen component were benzylamine, methyl amine or ammonium chloride, the reaction now also include anilines, similar to the earlier Povarov reaction.

Here, however, the alkene is electron-rich, so it reacts well with the immonium diene in an Inverse electron-demand Diels–Alder reaction.

Researchers have extended the Grieco three-component reaction to reactants or catalysts immobilized on solid support, which greatly expands the application of this reaction to various combinatorial chemistry settings.

Kobayashi and co-workers[4] show that a polymer-supported scandium catalyst catalyze the Grieco reaction with high efficiency.