The station is the terminus of both the Berner Oberland Bahn (BOB), whose trains operate services to Interlaken Ost, and of the Wengernalpbahn (WAB), whose trains operate to Kleine Scheidegg via Grindelwald Grund.

[1][4] The BOB and WAB lines use different gauges, and there is no physical connection between them.

Trains of both lines enter the station from its western end.

Counter-intuitively, the WAB commences its ascent to Kleine Scheidegg by descending steeply to Grindelwald Grund, where it reverses and commences its climb.

[1] As of the December 2020 timetable change,[update] the following rail services stop at Grindelwald:[5] Post bus services connect Grindelwald station to other local places, including a service to Meiringen over the Grosse Scheidegg Pass, using a road closed to most other traffic.