This 160-kilometre (99 mi) long river rises in the Sierra de Gúdar, near Villarroya de los Pinares and Miravete de la Sierra in the Maestrazgo, Aragon.

Flowing northeastwards its waters fill the Santolea reservoir, then the dam of Calanda, before it enters the Ebro at Caspe.

In addition to the towns mentioned, it also flows through Alcañiz and Civan.

Tributaries of the Guadalope include the Bergantes, Fortanete, Bordón and Mezquín on the right side, and the Aliaga River and the Guadalopillo on the left.

This article related to a river in Spain is a stub.