On August 1, 2010, the Camino Real de Tierra Adentro was inscribed by UNESCO on the World Heritage List, being the former Apostolic College of Propaganda Fide of Our Lady of Guadalupe, one of the sites on the cultural itinerary that reached this title, for its architectural richness and contribution to the evangelization of the north of New Spain.

According to the latest research, it is the year 1555, when Pedro de Ahumada Sámano obtained a land grant for small livestock three quarters of a league from the mines of Zacatecas, on the way to Mexico City, a place that would be known as San Nicolás de los Campos, located where the Arboledas, Campo Bravo and El Carmen neighborhoods are currently located.

Later, after obtaining the Royal Decree in January 1704 from Philip V of Spain, on January 12, 1707, the Apostolic College of Propaganda Fide of Our Lady of Guadalupe was founded by the Franciscans Antonio Margil de Jesús, José de Castro, José Guerra, Alonso González, Pedro Franco, José de San Francisco, among others; With the missionary work of this College, Guadalupe acquired great fame and reputation, since it was a Fide Propaganda Center for the promotion of the Christian faith, for a large portion of the northern area of the Viceroyalty of New Spain and a large part of the states from the south of what is now the United States.

At the local level, the figure of José María Rodríguez stands out, who together with the priest Antonio Torres and Víctor Rosales, conspired to surrender the capital to the insurgency.

However, in 1825 it was repealed to the rank of congregational board, not being until 1829 when it was again established as a City Council in accordance with the provisions of the Political Constitution of the State of Zacatecas.