The municipality of Mezquital del Oro lies at an elevation between 900 and 2,500 metres (3,000–8,200 ft) in the Sierra Madre Occidental in southwestern Zacatecas.

It also borders the Jaliscan municipalities of Ixtlahuacán del Río to the south and San Cristóbal de la Barranca to the southwest.

[4] Mezquital del Oro's climate ranges from temperate to tropical depending on elevation, with dry winters in either case.

[10] The municipal government of Mezquital del Oro comprises a president, a councillor (Spanish: síndico),[7] and seven trustees (regidores), four elected by relative majority and three by proportional representation.

[15] Federal Highway 23 runs through the westernmost corner of the municipality, connecting it to Jerez and Fresnillo in the north, and Zapopan and Guadalajara in the south.