The southernmost end of the range is also in the border region of Sonora, just north of Federal Highway 2.

The Guadalupe Mountains are a short sub-range, and about 13 mi long, north to south.

The north end of the range contains the highpoint of Guadalupe Mountain in the center west.

Guadalupe Spring is on its south, part of the headwaters of Guadalupe Creek-Guadalupe Canyon; to the east are the headwaters of Cloverdale Creek, which flows eastwards towards the ghost town site of Cloverdale.

At the center west of the range, adjacent the Arizona border, lies Bunk Robinson Peak, at 6,241 feet (1,902 m).