Guatemala competed at the 2012 Summer Olympics in London from 27 July to 12 August 2012.

Comité Olímpico Guatemalteco, sent the nation's largest delegation to the Games after the 1996 Summer Olympics in Atlanta.

A total of 19 athletes, 12 men and 7 women, competed in 11 sports and 21 distinct events.

Four Guatemalan athletes made their second consecutive Olympic appearance, including badminton player Kevin Cordón, and Laser sailor Juan Ignacio Maegli, who was the nation's flag bearer at the opening ceremony.

Pistol shooter Sergio Sánchez, who had participated in the Olympic games since 1992, was the oldest member of the contingent, at age 41.