Guatemala competed in the 2015 Pan American Games in Toronto, Ontario, Canada from July 10 to 26, 2015.

[1] Race walker Mirna Ortiz was the flagbearer at the head of the country's contingent at the opening ceremony.

Guatemala qualified two male archers based on its performance at the 2014 Pan American Championships.

Qualification Legend: FA=Final A (medal); FB=Final B (non-medal); R=Repechage Guatemala qualified 4 boats (five athletes).

*Note: Peruvian swimmer Mauricio Fiol was suspended by his team and pulled from the A final of the 100 meter butterfly for testing positive for stanozolol.

The team originally did not qualify, but after Puerto Rico declined its quota earned at the 2014 Central American and Caribbean Games in Veracruz, Mexico, the country was allowed to enter a duet as the first reserve.

Guatemala received a reallocated quota spot in the water skiing competitions.

[18][19] Guatemala's fourth athlete (Astrid Camposeco) tested positive for doping on May 23 (but results were determined only on July 9 when she was in Toronto and was disqualified before the games started.