Guyana competed in the 2015 Pan American Games in Toronto, Ontario, Canada from July 10 to 26, 2015.

[1] Guyana's team consisted of 22 athletes (19 men and three women) competing in five sports.

[2] Swimmer Onika George was the flagbearer for the team during the opening ceremony.

Guyana's track and field team consisted of three athletes (two men and one woman).

[4] Guyana received two quota spots to enter one male and one female.