Uruguay competed in the 2015 Pan American Games in Toronto, Canada from July 10 to 26, 2015.

[1] Sailor Dolores Moreira was named the flagbearer of the country at the opening ceremony, after track and field athlete Déborah Rodríguez could not arrive on time to Toronto due to flight problems.

Uruguay qualified five track and field athletes (three men and two women).

Uruguay has qualified a men's and women's pair for a total of four athletes.

[11] Cristhian Meneses Debora Reis Uruguay has qualified a men's and women's team.

Qualification Legend: FA=Final A (medal); FB=Final B (non-medal); R=Repechage Uruguay has qualified a men's team of 12 athletes.

[19] Diana Cabrera was a Canadian born shooter who competed in her hometown at the games for the country of her parents birth.