[1][2][a] Influenced by the early 1960s' avant-garde artistic culture in Torino and the radical architectural experimentation of the period, the Gugliermetto brothers began to explore new forms and new materials to use in the production of design projects.

Adapting materials such as polyurethane foam, which was widely used as a packing insulant in the transportation industry, allowed Gufram to manufacture entirely new and radical furniture typologies.

[citation needed] At the initiative of creative director Giuseppe Raimondi [it], who joined the company in 1966,[3][b] Gufram began collaborations with emerging artists of the time such as Ugo Nespolo and Piero Gilardi of the Arte Povera movement; architects Studio 65,[4] Guido Drocco and Franco Mello,[5] Giorgio Ceretti, Pietro Derossi [it] and Riccardo Rosso (Gruppo Strum [de]);[6][7] and the mathematician and theoretical physicist Tullio Regge, who "transformed a mathematical quartic function into a volume with intentionally ergonomic characteristics" for the design of his Detecma seat.

[citation needed] International recognition came in 1972 with an exhibition dedicated to Italian design entitled Italy: The New Domestic landscape, curated by Emilio Ambasz and staged at the Museum of Modern Art (MOMA) in New York, where they were first exposed,[9] and subsequently acquired for the museum's permanent collection.

The original Turin based company was acquired by the Poltrona Frau Group in 2004 and subsequently moved its headquarters to Tolentino.