Guglielmo Brezzi (Italian pronunciation: [ɡuʎˈʎɛlmo ˈbrettsi; ˈbreddzi]; 24 December 1898 – 7 April 1926) was an Italian professional footballer who played as a forward.
At club level, Brezzi played for Genoa C.F.C.
Brezzi made his debut for the Italy national football team on 18 January 1920 in a game against France and scored a hat-trick in a 9–4 victory.
He represented Italy at the 1920 Summer Olympics.
This biographical article related to association football in Italy, about a forward born in the 1890s, is a stub.