He was also husband of Bianca de' Medici, sister of the Lord of Florence Lorenzo the Magnificent.

He was one of nine children (three sons and six daughters) of Antonio di Andrea de' Pazzi and his wife Nicolosa degli Alessandri.

He was Priore of Liberty (1467), VIII of Balia and Guardia (1469), Officer of Monte (1471) and Mint Consul (1475).

In 1478 relations between the Medici and Pazzi had deteriorated for political, economic and personal reasons.

In 1501 he fought for Florence against Pisa and in 1502 he was Commissioner in Val di Chiana and Arezzo.