[3] Bianca was a daughter of Piero di Cosimo de' Medici and Lucrezia Tornabuoni.

[6] This alliance was intended to help resolve the animosity between the families, but it was not successful in that regard as Machiavelli noted in his Florentine Histories.

[9] In the aftermath of the Pazzi conspiracy of 1478, Bianca's marriage significantly softened Lorenzo's wrath towards Guglielmo, who was only put under house arrest for a time, while his male relatives were exiled or executed;[10] his daughters were exempted from the marriage ban imposed on other Pazzi daughters.

[12][2] Teodoro Montefeltro, the Apostolic protonotary travelling with the pope, praised the performance in a letter to Barbara of Brandenburg, Marquise of Mantua.

[2] In 1475, Bianca asked her mother to purchase farmland from other relatives for her, as Lucrezia had more influence within the family.