Guilford Wiley Wells (February 14, 1840 – March 21, 1909) was a Reconstruction-era U.S. Representative from Mississippi.

Born in Conesus Center, New York, Wells attended the Genesee Wesleyan Seminary and College in Lima.

He was admitted to the bar in 1867 and commenced practice in Holly Springs, Mississippi.

He served as United States Consul General in Shanghai, China, from June 23, 1877, to May 26, 1879.

This article incorporates public domain material from the Biographical Directory of the United States Congress